Evaluation of the genotoxicity potential and chronic inhalation toxicity of 1,1-dichloro-1-fluoroethane (HCFC-141 b)

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Metabolism of 1,1-dichloro-1-fluoroethane (HCFC-141b) in human volunteers.

Human subjects were exposed by inhalation to 250, 500, and 1000 ppm 1,1-dichloro-1-fluoroethane (HCFC-141b) for 4 hr, and urine samples were collected from 0-4, 4-12, and 12-24 hr for metabolite analysis. 19F nuclear magnetic resonance spectroscopic analysis of urine samples from exposed subjects showed that 2,2-dichloro-2-fluoroethyl glucuronide and dichlorofluoroacetic acid were the major and...

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ژورنال

عنوان ژورنال: Food and Chemical Toxicology

سال: 1995

ISSN: 0278-6915

DOI: 10.1016/0278-6915(95)00015-t